Scientific Consulting · Translational Medicine
Giuseppe Astarita
Ph.D. — Biochemistry & Molecular Biology
Senior scientific consulting for biotech and pharma teams that need actionable biomarkers, fit-for-purpose assays, and interpretable omics data across neuroscience, rare disease, metabolic disorders, inflammation, and nutrition.
I founded MyMetabolome to bring senior-level scientific expertise directly to the organizations that need it — without the overhead of a large consultancy. My work sits at the intersection of lipid biology, multi-omics mass spectrometry, and translational drug development.
Over two decades I have built omics platforms and biomarker programs from the ground up at Denali Therapeutics and Arkuda Therapeutics, advancing assets through proof-of-concept in Alzheimer's, Parkinson's, lysosomal storage disorders, frontotemporal dementia, and neuroinflammation. A particular focus has been lysosomal trafficking and its role in brain disease — including progranulin biology, GBA-related lipid dysregulation, and sphingolipid pathway alterations connecting lysosomal dysfunction to neurodegeneration. I have led CRO partnerships, shaped regulatory-facing evidence packages, and presented at Scientific Advisory Board (SAB) meetings.
My expertise extends well beyond neuroscience. I have applied multi-omics approaches to metabolic disorders (insulin resistance, hepatic steatosis, cardiometabolic disease), inflammation and immune biology (oxylipins, eicosanoids, endocannabinoid system), and nutrition and food science — areas interconnected at the level of lipid biology and metabolic pathway dysregulation.
What sets my work apart is depth in lipid biology — one of the fastest-growing areas in drug discovery and precision medicine — combined with the strategic and leadership experience to translate that science into portfolio-level decisions.
I also hold an adjunct faculty position at Georgetown University, where I lead NIH- and Alzheimer's Association-funded research and mentor the next generation of translational scientists.
Senior scientific expertise delivered directly — from early biomarker strategy through clinical execution and beyond.
End-to-end biomarker planning for clinical programs — defining MOA, pharmacodynamic, and patient stratification endpoints. Study design, protocol input, and regulatory-facing evidence packages.
Design and oversight of lipidomics, metabolomics, and proteomics workflows using LC-MS/MS and immunoassay platforms (Olink, SomaLogic). Targeted and untargeted approaches across plasma, CSF, serum, and tissue — spanning neurodegeneration, metabolic disorders, inflammation, and nutrition research.
Fit-for-purpose assay development and validation for translational and clinical biomarker readouts. CRO selection, oversight, and quality management to ensure regulatory-ready data.
Hypothesis generation, sample procurement strategy, experimental design, and power analysis for metabolomics and lipidomics studies. Preclinical-to-clinical translation, selection of internal standards, and analytical solutions tailored to classes of molecules of interest.
Strategic scientific input for drug development programs, pipeline decisions, and portfolio planning. Expert review of biomarker plans, regulatory documents, and clinical protocols.
Scientific writing, grant strategy, and publication support for academic and industry partners. Experienced in NIH, foundation, and industry-sponsored research frameworks.
High-throughput data processing, statistical analysis, pathway enrichment, and visualization for metabolomics and lipidomics datasets. Integration of multi-omics outputs with clinical and phenotypic data to extract actionable biological insights.
Specialized consulting for programs in cardiometabolic disease, insulin resistance, hepatic steatosis, and inflammatory conditions. Deep expertise in oxylipin profiling, eicosanoid biology, endocannabinoid signaling, and lipid mediator panels as pharmacodynamic and patient stratification endpoints.
Metabolomics and lipidomics applications in food science, nutritional research, and functional ingredients. Study design and biomarker strategies for omega-3/6 biology, dietary intervention trials, and food quality assessment.
Flexible structures to match where you are — from a one-time expert review to embedded, ongoing program leadership.
A fixed-scope deliverable with a clear timeline — a biomarker strategy, assay validation plan, study design, or data analysis package. Best when you know the question and need it answered well.
Monthly access to senior scientific judgment — on-call review of protocols, CRO outputs, and pipeline decisions. Best for teams that want continuity without a full-time hire.
Hands-on, part-time leadership of an omics or biomarker function — building platforms, hiring teams, and driving programs. Best for early-stage groups standing up capability.
Getting started is simple. Reach out with a short note about your program and where you need support. We'll have an initial call to scope the work and agree on the right format and timeline — no obligation. Start a conversation →
Anonymized highlights from MyMetabolome consulting engagements — spanning early-stage biotech, large pharma, and academic partnerships across translational programs.
Long-running advisory and analytical work across translational research programs. Multi-omics data analysis and biological interpretation supporting downstream publications and grant submissions.
Long-running advisory work guiding multi-omics laboratory setup, instrumentation selection, and recruitment of expert scientific teams for early-stage biotech ventures.
Advised on multi-omics integration strategy and commercial positioning for biotech and pharma clients spanning discovery and translational programs.
Established laboratory SOPs, instrumentation roadmap, and high-throughput mass spectrometry workflows for routine customer-facing analytical services.
Designed biomarker panel strategy for a clinical-stage program. Defined fluid biomarker selection, assay readiness criteria, and translational endpoints.
Advised on assay development for biomarkers and enzymatic activity measurements in CSF and plasma matrices to support translational and clinical-stage programs.
Analyzed and presented microbiome multi-omics datasets. Findings contributed to patent applications.
Client identities withheld under standard consulting confidentiality. References available on request for serious inquiries.
Two decades spanning academia, CRO, and biopharma — from platform building to senior program leadership.
I work with biotech and pharma companies, CROs, startups, and academic groups at any stage — from early platform strategy to late-phase clinical biomarker execution. If you're looking for senior scientific expertise in lipidomics, metabolomics, translational biomarker strategy, experimental design, or data analysis and interpretation across neuroscience, metabolic disorders, inflammation, or nutrition research, I'd welcome a conversation.