Scientific Consulting · Translational Medicine

Giuseppe Astarita

Ph.D. — Biochemistry & Molecular Biology

Translational scientist specializing in biomarker strategy, multi-omics, and experimental design. Twenty years at the intersection of lipidomics, metabolomics, and clinical science — across neuroscience, metabolic disorders, inflammation, and nutrition.

90+
Peer-Reviewed Publications
13K+
Citations
54
h-index
16
Granted Patents
Lipidomics Metabolomics Proteomics Biomarker Strategy LC-MS/MS Translational Neuroscience Metabolic Disorders Inflammation Rare Disease Nutrition & Food Science

Twenty years translating biology into decisions

I founded MyMetabolome to bring senior-level scientific expertise directly to the organizations that need it — without the overhead of a large consultancy. My work sits at the intersection of lipid biology, multi-omics mass spectrometry, and translational drug development.

Over two decades I have built omics platforms and biomarker programs from the ground up at Denali Therapeutics and Arkuda Therapeutics, advancing assets through proof-of-concept in Alzheimer's, Parkinson's, lysosomal storage disorders, frontotemporal dementia, and neuroinflammation. A particular focus has been lysosomal trafficking and its role in brain disease — including progranulin biology, GBA-related lipid dysregulation, and sphingolipid pathway alterations connecting lysosomal dysfunction to neurodegeneration. I have led CRO partnerships, shaped regulatory-facing evidence packages, and presented at Scientific Advisory Board (SAB) meetings.

My expertise extends well beyond neuroscience. I have applied multi-omics approaches to metabolic disorders (insulin resistance, hepatic steatosis, cardiometabolic disease), inflammation and immune biology (oxylipins, eicosanoids, endocannabinoid system), and nutrition and food science — areas interconnected at the level of lipid biology and metabolic pathway dysregulation.

What sets my work apart is depth in lipid biology — one of the fastest-growing areas in drug discovery and precision medicine — combined with the strategic and leadership experience to translate that science into portfolio-level decisions.

I also hold an adjunct faculty position at Georgetown University, where I lead NIH- and Alzheimer's Association-funded research and mentor the next generation of translational scientists.

What I Offer

Consulting Services

Senior scientific expertise delivered directly — from early biomarker strategy through clinical execution and beyond.

01

Biomarker Strategy

End-to-end biomarker planning for clinical programs — defining MOA, pharmacodynamic, and patient stratification endpoints. Study design, protocol input, and regulatory-facing evidence packages.

02

Multi-Omics Platform Design

Design and oversight of lipidomics, metabolomics, and proteomics workflows using LC-MS/MS and immunoassay platforms (Olink, SomaLogic). Targeted and untargeted approaches across plasma, CSF, serum, and tissue — spanning neurodegeneration, metabolic disorders, inflammation, and nutrition research.

03

Assay Development & Validation

Fit-for-purpose assay development and validation for translational and clinical biomarker readouts. CRO selection, oversight, and quality management to ensure regulatory-ready data.

04

Experimental & Study Design

Hypothesis generation, sample procurement strategy, experimental design, and power analysis for metabolomics and lipidomics studies. Preclinical-to-clinical translation, selection of internal standards, and analytical solutions tailored to classes of molecules of interest.

05

Scientific Advisory

Strategic scientific input for drug development programs, pipeline decisions, and portfolio planning. Expert review of biomarker plans, regulatory documents, and clinical protocols.

06

Grant & Publication Support

Scientific writing, grant strategy, and publication support for academic and industry partners. Experienced in NIH, foundation, and industry-sponsored research frameworks.

07

Data Analysis & Interpretation

High-throughput data processing, statistical analysis, pathway enrichment, and visualization for metabolomics and lipidomics datasets. Integration of multi-omics outputs with clinical and phenotypic data to extract actionable biological insights.

08

Metabolic Disorders & Inflammation

Specialized consulting for programs in cardiometabolic disease, insulin resistance, hepatic steatosis, and inflammatory conditions. Deep expertise in oxylipin profiling, eicosanoid biology, endocannabinoid signaling, and lipid mediator panels as pharmacodynamic and patient stratification endpoints.

09

Nutrition & Food Science

Metabolomics and lipidomics applications in food science, nutritional research, and functional ingredients. Study design and biomarker strategies for omega-3/6 biology, dietary intervention trials, and food quality assessment.

Career

Selected Experience

Two decades spanning academia, CRO, and biopharma — from platform building to senior program leadership.

2022 — 2023
Senior Director, Biomarker Discovery
Arkuda Therapeutics · Watertown, MA
Led biomarker strategy for clinical-stage programs in neuroinflammation and lysosomal biology. Built integrated multi-omics pipelines (LC-MS/MS, Olink, SomaLogic). Managed CRO partnerships and regulatory-ready assay validation programs.
2020 — Present
Principal Consultant
MyMetabolome Consulting · Belmont, MA
Advising biotech and pharma clients on translational biomarker strategy, multi-omics platform design, and clinical study integration across neuroscience, rare disease, and metabolic disorders.
2020 — 2022
Senior Scientific Manager
Metabolon · San Francisco, CA
Delivered global metabolomics, lipidomics, and proteomics solutions for pharma and biotech clients. Scientific leadership in experimental design, platform selection, and biomarker interpretation.
2016 — 2020
Principal Scientist, Head of Omics Mass Spectrometry
Denali Therapeutics · South San Francisco, CA
Built centralized multi-omics MS platform supporting biomarker discovery across Alzheimer's, Parkinson's, and lysosomal storage disorder programs. Multiple assets advanced to proof-of-concept. Co-authored 8 publications and co-invented 4 patents.
2011 — 2016
Principal Scientist & Strategic Manager
Waters Corporation · Milford, MA
Advanced LC-MS technologies for lipidomics and metabolomics. Contributed to instrument development, publications, and intellectual property in translational biomarker applications.
2012 — Present
Adjunct Assistant Professor
Georgetown University · Washington, DC
NIH- and Alzheimer's Association-funded research in lipidomics and omics biosignatures in neurodegenerative disease. Teaching and mentorship in translational mass spectrometry.
Scientific Record

Publications & Patents

90+
Publications
13,000+
Citations
54
h-index
16
Granted Patents
2024
Metabolomics and Lipidomics Strategies in Modern Drug Discovery and Development
Drug Discovery Today · Astarita G., Kelly R., Lasky-Su J.
2023
Granulins Rescue Inflammation, Lysosome Dysfunction, Lipofuscin, and Neuropathology in a Mouse Model of Progranulin Deficiency
Cell Reports · Root J., Mendsaikhan A., Taylor G., ... Astarita G. et al.
2022
Ion Mobility Mass Spectrometry in the Omics Era: Challenges and Opportunities for Metabolomics and Lipidomics
Wiley Analytical Science · Astarita G. et al.
Get In Touch

Work Together

I work with biotech and pharma companies, CROs, startups, and academic groups at any stage — from early platform strategy to late-phase clinical biomarker execution. If you're looking for senior scientific expertise in lipidomics, metabolomics, translational biomarker strategy, experimental design, or data analysis and interpretation across neuroscience, metabolic disorders, inflammation, or nutrition research, I'd welcome a conversation.

Location Belmont, MA · Greater Boston